abstract：OBJECTIVE:Syndecan-1 is a cell surface heparan sulphate proteoglycan which participates in cell proliferation, cell migration and cell-matrix interactions. Epithelial syndecan-1 expression is reduced in several malignant tumours, but in breast and pancreatic cancer, increased expression has also been described. Loss of...

journal_title：Oncology

authors： Leivonen M,Lundin J,Nordling S,von Boguslawski K,Haglund C

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:ETS-1 has been identified as a proto-oncogene and a transcription factor for tumor angiogenesis, which is essential for the growth, invasion and metastasis of solid tumors. The aim is to investigate the clinical implications of ETS-1 expression in peritoneal metastatic lesions of ovarian cancers. METHODS:In ...

journal_title：Oncology

authors： Fujimoto J,Aoki I,Toyoki H,Khatun S,Sato E,Sakaguchi H,Tamaya T

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:New effective therapy is desirable for patients with non-small cell lung cancer (NSCLC) who have failed previous treatments. Fractionated administration of paclitaxel may be less toxic and more active against NSCLC. The aim of this study was to evaluate the activity and toxicity of weekly paclitaxel therapy f...

journal_title：Oncology

authors： Yasuda K,Igishi T,Kawasaki Y,Kato K,Matsumoto S,Katayama S,Sako T,Shigeoka Y,Suyama H,Sugitani A,Yamamoto M,Hitsuda Y,Shimizu E

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVES:Calcitriol, 1alpha,25-dihydroxyvitamin D(3) (1,25-D(3)) has potent antiproliferative effects and potentiates the antitumor activity of many other cytotoxic drugs. 1,25-D(3) plasma pharmacokinetic (PK) parameters associated with antitumor activity in experimental animal models are unknown. The objective of th...

journal_title：Oncology

authors： Muindi JR,Modzelewski RA,Peng Y,Trump DL,Johnson CS

更新日期：2004-01-01 00:00:00

abstract：OBJECTIVE:Expression of vascular endothelial growth factor (VEGF)-D by tumors is associated with metastasis to lymph nodes in mice. However, there are few reports concerning the clinical significance of VEGF-D protein in human carcinoma. METHODS:After confirming production of VEGF-D by eight colorectal carcinoma cell ...

journal_title：Oncology

authors： Funaki H,Nishimura G,Harada S,Ninomiya I,Terada I,Fushida S,Tani T,Fujimura T,Kayahara M,Shimizu K,Ohta T,Miwa K

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Anaplastic oligodendrogliomas (AO) are uncommon primary brain tumors whose natural history, prognosis, and optimal management are not yet fully understood. However, they are associated with a better prognosis and response to multimodality therapy based on specific molecular changes. In this multicenter retro...

journal_title：Oncology

authors： Puduvalli VK,Hashmi M,McAllister LD,Levin VA,Hess KR,Prados M,Jaeckle KA,Yung WK,Buys SS,Bruner JM,Townsend JJ,Davis R,Sawaya R,Kyritsis AP

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:Insulin-like growth factor I (IGF-I) and other components of the IGF system have been implicated in the etiology of several human malignancies. We have undertaken a case-control study among Greek women to explore the relation of major components of the IGF system (IGF-I, IGF-II and IGF-binding protein 3, IGF...

journal_title：Oncology

authors： Petridou E,Koukoulomatis P,Alexe DM,Voulgaris Z,Spanos E,Trichopoulos D

更新日期：2003-01-01 00:00:00

abstract：:Aberrant glycosylation of membrane components due to specific alterations of glycosyltransferase activity is a common feature of carcinoma cells and is usually associated with invasion and metastasis. In a prospective study, the enzyme activity of the sialyltransferases ST6GAL-I and ST3GAL-III was studied in gastric c...

journal_title：Oncology

authors： Gretschel S,Haensch W,Schlag PM,Kemmner W

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy and safety of neoadjuvant treatment comprising weekly high-dose 5-fluorouracil (5-FU) as a 24-hour infusion, folinic acid (FA) and biweekly oxaliplatin (L-OHP), followed by metastatic resection in patients with primarily resectable liver metastases of colorectal cancer (CRC). PATIENTS ...

journal_title：Oncology

authors： Wein A,Riedel C,Brückl W,Merkel S,Ott R,Hanke B,Baum U,Fuchs F,Günther K,Reck T,Papadopoulos T,Hahn EG,Hohenberger W

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVE:There are a few long-term follow-up studies of patients with stage I ovarian carcinoma. The objective of this study was to evaluate prognostic factors for long-term survival. METHODS:Two hundred fourteen stage I ovarian carcinomas (registered by the Tokai Ovarian Tumor Study Group from 1988 to 1999) were ana...

journal_title：Oncology

authors： Mizuno M,Kikkawa F,Shibata K,Kajiyama H,Suzuki T,Ino K,Kawai M,Mizutani S

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:The association oxaliplatin (OXA)-5-fluorouracil/folinic acid (FUFA) is currently a standard first-line treatment for advanced colorectal cancer. The main objective of this experimental study was to examine the cytotoxic effects resulting from the addition of ionizing radiation (Rgamma) to the co...

journal_title：Oncology

authors： Magné N,Fischel JL,Formento P,Etienne MC,Dubreuil A,Marcié S,Lagrange JL,Milano G

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relationship between the histopathologic effects of preoperative chemoradiotherapy in rectal cancer and the proteins, proliferating cell nuclear antigen (PCNA) and p53. METHODS:Samples from 73 tumors were examined. The histopathologic effects observed in the resected specimens induced by ...

journal_title：Oncology

authors： Díez M,Ramos P,Medrano MJ,Mugüerza JM,Villeta R,Lozano O,Escribano J,Noguerales F,Ruíz A,Granell J

更新日期：2003-01-01 00:00:00

abstract：:Ifosfamide is one of the best-known alkylating agents. In advanced epithelial ovarian cancer, it has been tested in association with cisplatin, achieving results equal, if not better than cyclophosphamide, with acceptable toxicity. In second-line therapy, it shows remarkable activity, even in patients refractory to ci...

journal_title：Oncology

authors： Lissoni AA,Fei F,Rossi R,Fruscio R,Villa A,Zani G

更新日期：2003-01-01 00:00:00

abstract：:Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...

journal_title：Oncology

authors： Klastersky J

更新日期：2003-01-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine the prognostic value of the preoperative serum alpha-L-fucosidase (AFU) activity in colorectal cancer and to assess whether it could add prognostic information that Dukes' stages do not give. METHODS:A postoperative follow-up of 137 colorectal cancer patients was perform...

journal_title：Oncology

authors： Ayude D,Páez De La Cadena M,Martínez-Zorzano VS,Fernández-Briera A,Rodríguez-Berrocal FJ

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:It is well recognized that distinguishing benign from malignant papillary lesions of the breast may pose challenging diagnostic problems. To prospectively evaluate the potential role of mammography, ultrasound and image-guided core biopsy in the diagnosis of papillary lesions of the breast. METHODS:1,442 wo...

journal_title：Oncology

authors： Puglisi F,Zuiani C,Bazzocchi M,Valent F,Aprile G,Pertoldi B,Minisini AM,Cedolini C,Londero V,Piga A,Di Loreto C

更新日期：2003-01-01 00:00:00

abstract：:As the antitumor activity of radiation is mediated via its interaction with oxygen to form labile free radicals, the intratumoral oxygen level has an important influence on the ability of radiation therapy to kill malignant cells. By decreasing the oxygen-carrying capacity of the blood, anemia may result in tumor hypo...

journal_title：Oncology

authors： Harrison LB,Shasha D,Homel P

更新日期：2002-01-01 00:00:00

abstract：:Abundant expression of thymidine phosphorylase (TP) mRNA and protein was observed in human carcinoma tissues relative to the corresponding normal tissues. However, the distribution of cells that express TP has not yet been determined. In this study, we examined enzyme activity of TP in 24 primary colorectal carcinoma ...

journal_title：Oncology

authors： Mimori K,Matsuyama A,Yoshinaga K,Yamashita K,Masuda T,Inoue H,Ueo H,Mori M

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:To define the cyclophosphamide (CTX) maximal tolerated dose when combined with fixed doses of gemcitabine, fluorouracil (5-FU) and folinic acid (leucovorin, LFA) in metastatic breast cancer patients pretreated with anthracyclines and taxanes. METHODS:Metastatic breast cancer patients aged < or = 75 years, with...

journal_title：Oncology

authors： Frasci G,D'Aiuto G,Comella P,Thomas R,Capasso I,Botti G,Cortino GR,Di Bonito M,Rubulotta R,Vallone P,Comella G

更新日期：2002-01-01 00:00:00

abstract：:Improved understanding of tumor biology has led to the identification of numerous growth factors that are involved in malignant transformation and tumor progression. Many of these factors induce cellular responses through receptors with intrinsic tyrosine kinase (TK) activity. Therefore, inhibiting receptor TK activit...

journal_title：Oncology

authors： Baselga J,Hammond LA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:Anti-p53 levels detected by different methods were compared in a predefined group of patients with breast cancer and correlated with p53 antigen expression in the corresponding tumors. METHODS:P53 autoantibodies were investigated in 165 patients with primary breast cancer using ELISAs with recombinant or nat...

journal_title：Oncology

authors： Volkmann M,Sinn HP,Gaugel D,Frey M,Hajjar Y,Ludwig J,Hänsel S,Bastert G,Wallwiener D,Fiehn W,Zentgraf H,Huober J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND AND AIM:In vitro, methotrexate (MTX) is the best modulator for bolus 5-fluorouracil (5FU), whereas folinic acid (FA) is the best for continuous infusion. We evaluated the effect of 5FU modulated by both MTX (bolus administration) and FA (continuous infusion) as second-line treatment of patients with metastat...

journal_title：Oncology

authors： Carlomagno C,Lauria R,De Laurentiis M,Arpino G,Massarelli E,Ferrara C,Milano A,Vernaglia Lombardi A,Costanzo R,Catalano G,Bianco AR,De Placido S

更新日期：2002-01-01 00:00:00

abstract：:Loss of heterozygosity (LOH) on chromosomes 13q, 16q and 17p has been associated with the progression of hepatocellular carcinoma (HCC). To investigate the prognostic impact of such LOH, we examined the metastasis-free survival of curatively resected HCC cases, in whom these LOHs were analyzed. Among the 49 HCC patien...

journal_title：Oncology

authors： Nishida N,Fukuda Y,Komeda T,Ito T,Nishimura T,Minata M,Kuno M,Katsuma H,Ikai I,Yamaoka Y,Nakao K

更新日期：2002-01-01 00:00:00

abstract：:Surgery for hepatocellular carcinoma has improved dramatically during the last two decades, and the improvement is mainly attributable to the development of intraoperative ultrasound-guided operative procedures such as Makuuchi's segmentectomy, introduction of the intermittent vascular occlusion technique, and establi...

journal_title：Oncology

authors： Makuuchi M,Imamura H,Sugawara Y,Takayama T

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Variations in the incidence of cancer can be influenced by diet and specific lifestyles. In the last years, diet has been evaluated as an important factor in the development of ovarian cancer, even though the results have not been consistent. Dietary factors related to the risk of ovarian cancer in Mexican w...

journal_title：Oncology

authors： Salazar-Martinez E,Lazcano-Ponce EC,Gonzalez Lira-Lira G,Escudero-De los Rios P,Hernandez-Avila M

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The tumor suppressor gene p53 is a nuclear protein which plays a key role in tumor progression by regulating DNA repair, cell division and apoptosis. One major function of wild-type p53 is to control the onset of DNA replication at the G1-S boundary by inducing p21 protein, which promotes cell cycle arrest b...

journal_title：Oncology

authors： Okuyama T,Maehara Y,Kabashima A,Takahashi I,Kakeji Y,Sugimachi K

更新日期：2002-01-01 00:00:00

abstract：:Zinostatin stimalamer (SMANCS) is a lipophilic intra-arterial chemotherapeutic agent for hepatocellular carcinoma (HCC). In our previous study, transcatheter arterial infusion chemotherapy using SMANCS for HCC showed a response rate of 20%. In an effort to obtain a superior anti-tumor effect against HCC, we conducted ...

journal_title：Oncology

authors： Okusaka T,Okada S,Ueno H,Ikeda M,Iwata R,Furukawa H,Takayasu K,Moriyama N,Sato T,Sato K

更新日期：2002-01-01 00:00:00

abstract：:Irinotecan and raltitrexed are active against advanced colorectal cancer, act through different mechanisms, and have non-overlapping toxicity profiles. In vitro studies have shown a schedule-dependent synergism between both drugs. The aim of this multicenter study was to determine the maximum tolerated dose (MTD) of t...

journal_title：Oncology

authors： Aparicio J,de las Peñas R,Vicent JM,Garcerá S,Llorca C,Maestu I,Yuste AL,Farrés J

更新日期：2002-01-01 00:00:00

abstract：:The cytochrome P450 CYP2D6 is a polymorphic drug-metabolizing enzyme that is involved in the metabolism of several drugs and xenobiotics. Several independent studies indicate that the CYP2D6 metabolic status is a secondary factor in the risk of developing lung cancer, with individuals with high activity being at incre...

journal_title：Oncology

authors： Agúndez JA,Gallardo L,Ledesma MC,Lozano L,Rodriguez-Lescure A,Pontes JC,Iglesias-Moreno MC,Poch J,Ladero JM,Benítez J

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To evaluate the feasibility of conducting a patient satisfaction survey in the oncology hospital setting, using a multidimensional patient satisfaction questionnaire to be completed at home. METHODS:Socio-demographic and clinical data were collected for 133 consecutive patients. Patients were asked to comple...

journal_title：Oncology

authors： Brédart A,Razavi D,Robertson C,Didier F,Scaffidi E,Fonzo D,Autier P,de Haes JC

更新日期：2001-01-01 00:00:00

abstract：:Primary pancreatic lymphoma (PL) is an extremely rare disease, and large-scale studies are rarely performed even in Western countries, in which all cases of PL reported to date were of the B-cell type. Little information regarding PL is available in Japan. Nineteen cases of PL were collected through a nationwide study...

journal_title：Oncology

authors： Nishimura R,Takakuwa T,Hoshida Y,Tsujimoto M,Aozasa K

更新日期：2001-01-01 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) is considered to be potentially lymphangiogenic and can selectively induce hyperplasia of the lymphatic vasculature. In this study, we clarified the clinicopathological features of early gastric carcinoma (EGC) that has metastasized to the lymph nodes, as well as the corre...

journal_title：Oncology

authors： Kabashima A,Maehara Y,Kakeji Y,Sugimachi K

更新日期：2001-01-01 00:00:00

abstract：:HER2 amplification/overexpression is a marker of poor prognosis in breast cancer. The prognostic impact of HER2 positivity is lower in node-negative compared with node-positive women. The only significant, independent prognostic factors in breast cancer are node status, HER2 status and menopausal status. HER2-positive...

journal_title：Oncology

authors： Ménard S,Fortis S,Castiglioni F,Agresti R,Balsari A

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVE:To better determine docetaxel activity in patients with well-defined anthracycline-resistant breast cancer. METHODS:From October 1996, we carried out a phase II trial in 69 heavily pretreated patients with advanced breast cancer with docetaxel 100 mg/m(2) by a 1-hour infusion on day 1, with cycles repeated e...

journal_title：Oncology

authors： Vici P,Belli F,Di Lauro L,Amodio A,Conti F,Foggi P,Gionfra T,Morelli MF,Botti C,Ferraironi A,Lopez M

更新日期：2001-01-01 00:00:00

abstract：:Objective tumor responses and survival rates with standard chemotherapy options for small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC) have been disappointing. However, several promising new classes of agents have emerged in recent years, including the taxanes, mitotic spindle inhibitors, antimetabol...

journal_title：Oncology

authors： Huang CH,Treat J

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES AND METHODS:Tumor dormancy and resistance to cytotoxic agents are key limiting events in the treatment of malignant diseases. To determine whether both are influenced by the extracellular milieu in which tumors reside, HT1080 human fibrosarcoma, MCF-7 breast carcinoma and OSCORT osteosarcoma cell proliferati...

journal_title：Oncology

authors： Pogány G,Timár F,Oláh J,Harisi R,Polony G,Paku S,Bocsi J,Jeney A,Laurie GW

更新日期：2001-01-01 00:00:00

abstract：PURPOSE:Breast cancer (BC) is the most frequent female carcinoma and the major cause of death in women aged 35--50 years. The total number of patients surviving BC and especially the morbidity rate of patients below the age of 55 years has increased significantly in the last several years. As a consequence, the number ...

journal_title：Oncology

authors： Beckmann MW,Jap D,Djahansouzi S,Nestle-Krämling C,Kuschel B,Dall P,Brumm C,Bender HG

更新日期：2001-01-01 00:00:00

abstract：OBJECTIVES:Systematic investigation of a novel series of intercalating agents, 9-aza-anthrapyrazoles, has led to the identification of a promising analogue, BBR 3438. This study describes the antitumour efficacy of the novel compound in human prostate carcinoma models and the molecular/cellular basis of its activity. ...

journal_title：Oncology

authors： Supino R,Polizzi D,Pavesi R,Pratesi G,Guano F,Capranico G,Palumbo M,Sissi C,Richter S,Beggiolin G,Menta E,Pezzoni G,Spinelli S,Torriani D,Carenini N,Dal Bo L,Facchinetti F,Tortoreto M,Zunino F

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Brain metastases develop frequently in patients with non-small cell lung cancer (NSCLC), and the prognosis for these patients is very poor. We evaluated the role of chemotherapy for patients with brain metastases from NSCLC. METHODS:We analyzed 30 patients who were discovered to have brain metastases during...

journal_title：Oncology

authors： Fujita A,Fukuoka S,Takabatake H,Tagaki S,Sekine K

更新日期：2000-11-01 00:00:00

abstract：:Little is known about the expression and antioxidant function of manganese superoxide dismutase (Mn-SOD) in esophageal squamous cell carcinoma. To determine the significance of Mn-SOD in esophageal squamous cell carcinomas, Mn-SOD mRNA expression was examined in 45 esophageal squamous cell carcinomas and the correspon...

journal_title：Oncology

authors： Toh Y,Kuninaka S,Mori M,Oshiro T,Ikeda Y,Nakashima H,Baba H,Kohnoe S,Okamura T,Sugimachi K

更新日期：2000-09-01 00:00:00